Wanjiru clocked two hours five minutes 10 seconds to better compatriot Martin Lel's course record by five seconds. Defending champion Lel, who was aiming for a record fourth London win, withdrew on Saturday because of a hip strain.
Germany's Irina Mikitenko retained the women's title after repelling a spirited challenge from Britain's Mara Yamauchi.
A trio of pacemakers took the men's field through the halfway point on a sunny spring morning in 61 minutes 35 seconds, the fastest ever split in a marathon.
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